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IL-12 production in SLE is down-regulated by excessive production of IL-10

✍ Scribed by Tie Fu Liu; Brian M. Jones


Book ID
108408972
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
360 KB
Volume
56
Category
Article
ISSN
0165-2478

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IL-18 (interferon-inducing factor) and IL-12 exhibit a marked synergism in interferon-gamma induction in T cells. Investigations into the mechanism of this synergism have revealed that IL-12 upregulates expression of the IL-18 receptor on cells producing interferon-gamma. Although IL-18 does not ind