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IL-10 is critical in the regulation of automimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice

✍ Scribed by E. Bettelli; M.P. Das; E. Howard; H. Weiner; R. Sobel; V. Kuchroo


Book ID
114138576
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
115 KB
Volume
90
Category
Article
ISSN
0165-5728

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## Abstract In Th1 and Th2 memory lymphocytes, the genes for the cytokines interleukin (IL)‐4 and interferon‐γ (IFN‐γ) are imprinted for expression upon restimulation. This cytokine memory is based on expression of the transcription factors T‐bet for IFN‐γ, and GATA‐3 for IL‐4, and epigenetic modif