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IL-1 increases ceramide production and induces COX-2 in intestinal epithelial cells

✍ Scribed by Homaidan, F.R.; El-Assaad, W.; Chakroun, I.; Dbaibo, G.; El-Sabban, M.E.


Book ID
123245522
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
168 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Abstract Cyclooxygenase (COX)‐2 derived prostaglandins (PGs) play a major role in intestinal inflammation and colorectal carcinogenesis. Because COX‐2 is the rate‐limiting step in the production of PGs, mechanisms that regulate COX‐2 expression control PG production in the cell. Using the non‐tu