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IL-1 acts on T cells to enhance the magnitude of in vivo immune responses

✍ Scribed by S.Z. Ben-Sasson; Stephane Caucheteux; Michelle Crank; Jane Hu-Li; William E. Paul

Book ID
116400080
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
213 KB
Volume
56
Category
Article
ISSN
1043-4666

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## Abstract The basis of the adjuvant effect of IL‐1 on the clonal expansion of Ag‐specific CD4 T cells was measured __in vivo__ using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus IL‐1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag al