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Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation

✍ Scribed by Nicole Avitahl; Susan Winandy; Christof Friedrich; Beverly Jones; Yimin Ge; Katia Georgopoulos


Book ID
117722462
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
525 KB
Volume
10
Category
Article
ISSN
1074-7613

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## Abstract T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The C