Ig/myc translocations of the plasmacytoma-prone BALB/c strain occur independently of the genetic and parental origin of the affected chromosomes 6, 12, and 15

✍ Scribed by Santiago Silva; Magdalena Babonits; George Klein

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 548 KB
• Volume: 17
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/(sici)1098-2264(199611)17:3<179::aid-gcc6>3.0.co;2-1

✦ Synopsis

Virtually all murine plasmacytomas (MPCs) carry chromosomal translocations that juxtapose rnyc on chromosome I 5 (chr IS) t o one of the three immunoglobulin loci carrying chr 6, 12, or 16. Only some mouse strains are susceptible t o MPC induction, however, with BALB/c as the outstanding example. Most other strains are resistant. Our earlier studies with reciprocal BALB/cc*DBA/2 chimeras suggested that part of this susceptibility is determined at the level of the target cell itself (DBA/2 is MPC resistant). The probability of the Iglrnyc translocation is one of the possibly relevant variables. Because MPC resistance is dominant over susceptibility, it is conceivable that the translocations prevail due t o some deficiency of the lg rearrangement or Ig-associated repair mechanisms in BALB/c cells. This could be determined at the level of the chromosomes that participate in the translocation o r by genes on other chromosomes. Here, we show that the substitution of the BALB/c-derived chr 12, 6, and 15, which carry IgH, K, and rnyc, respectively, with their homologs derived from MPC-resistant mice, did not affect MPC Susceptibility. The use of Robertsonian 4. I 2 and 6. I 5 chromosomes in this study has also provided us with the opportunity t o