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IgM-restricted production of immunoglobulin by lymphoid cell lines from patients with immunodeficiency with hyper IgM (dysgammaglobulinemia)

✍ Scribed by Jerrold F. Schwaber; Herbert Lazarus; Fred S. Rosen


Book ID
118373862
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
472 KB
Volume
19
Category
Article
ISSN
1090-2341

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## Abstract We studied the ability of B lymphocytes from patients with X‐linked hyper IgM syndrome (HIGM1) to be activated via the CD40 membrane receptor. HIGM1 is caused by a CD40 ligand gene mutation, leading to defective expression on the membrane of activated T lymphocytes. We found that trigge