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IgGs containing λ- and κ-type light chains and of all subclasses (IgG1–IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA

✍ Scribed by Taisiya A. Parkhomenko; Valentina N. Buneva; Boris M. Doronin; Margarita V. Volkova; Sergey A. Senkovich; Igor I. Generalov; Georgy A. Nevinsky

Book ID: 112133005
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 560 KB
Volume: 25
Category: Article
ISSN: 0952-3499
DOI: 10.1002/jmr.2185

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IgGs containing light chains of the λ and κ type and of all subclasses (IgG1-IgG4) from sera of patients with multiple sclerosis hydrolyze DNA

✍ Taisiya A. Parkhomenko; Galina A. Legostaeva; Boris M. Doronin; Valentina N. Bun 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 359 KB

## Abstract We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1–IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1 h) increases in the order: IgG1 (0.58) < IgG2 (0.94) < IgG3