๐”– Bobbio Scriptorium
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IgG antibodies to human herpesvirus-6 in young children: Changes in avidity of antibody correlate with time after infection

โœ Scribed by Dr. K. N. Ward; J. J. Gray; M. W. Fotheringham; M. J. Sheldon

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
743 KB
Volume
39
Category
Article
ISSN
0146-6615

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โœฆ Synopsis

Sera from 321 children aged 0-179 weeks and 196 adult blood donors were examined for IgG antibodies to human herpesvirus-6 (HHV-6) using an indirect immunofluorescence test. After birth, antibody prevalence declined to a minimum between 20 and 29 weeks. Thereafter the percentage of individuals with antibody increased up to the age of 60-69 weeks after which the prevalence of antibody in the children remained stable at about 88%; in contrast, the seroprevalence in blood donors was 98%, indicating that some individuals remain susceptible to infection after early childhood but that virtually all are infected by the time they reach adulthood.

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