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IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase

โœ Scribed by Ron Kooijman; Astrid Coppens; Elisabeth Hooghe-Peters


Book ID
114283835
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
326 KB
Volume
15
Category
Article
ISSN
0898-6568

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi