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IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

✍ Scribed by Sandrine Willaime-Morawek; Nicolas Arbez; Jean Mariani; Bernard Brugg


Book ID
119328542
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
490 KB
Volume
142
Category
Article
ISSN
0169-328X

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## Abstract We have previously shown that intrastriatal injection of ΔRR, the growth‐compromised herpes simplex virus type 2 (HSV‐2) vector for the antiapoptotic protein ICP10PK, prevents apoptosis caused by the excitotoxin N‐methyl‐D‐aspartate (NMDA) in a mouse model of glutamatergic neuronal cell