## Withdrawal of trophic factors necessary for Schwann cell survival regulates Schwann cell number during development and after nerve injury. In the present study, we identified signaling pathways involved in Schwann cell survival by prosaposin, prosaptides (peptides incorporating the neurotrophic
IGF-I promotes Schwann cell motility and survival via activation of Akt
β Scribed by Hsin-Lin Cheng; Matthew Steinway; Catherine L Delaney; Thomas F Franke; Eva L Feldman
- Book ID
- 117462528
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 135 KB
- Volume
- 170
- Category
- Article
- ISSN
- 0303-7207
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Activated phosphoinositide 3βkinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3KβAkt signaling pathway in the invasion of
## Abstract Phenotypic remodeling of Schwann cells is required to ensure successful regeneration of damaged peripheral axons. After nerve damage, Schwann cells produce an over 100βfold increase in metalloproteinaseβ9 (MMPβ9), and therapy with an MMP inhibitor increases the number of resident (but n