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IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells

✍ Scribed by Chi-Ming Wu; Te-Mao Li; Sheng-Feng Hsu; Yi-Chang Su; Shung-Te Kao; Yi-Chin Fong; Chih-Hsin Tang

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
482 KB
Volume
226
Category
Article
ISSN
0021-9541

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✦ Synopsis

Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Integrins are the major adhesive molecules in mammalian cells and have been associated with metastasis of cancer cells. Insulin-like growth factor-I (IGF)-I plays an important role in regulating cell growth, proliferation, survival, and metabolism. However, the effects of IGF-I in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IGF-I increased the migration and the expression of a5b1 integrin in human chondrosarcoma cells. Pretreatment of cells with IGF-I receptor antibody reduced IGF-I-induced cell migration and integrin expression. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and nuclear factor-kB (NF-kB) pathways after IGF-I treatment were demonstrated, and IGF-Iinduced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and NF-kB cascades. Taken together, our results indicated that IGF-I enhances the migration of chondrosarcoma cells by increasing a5b1 integrin expression through the IGF-I receptor/PI3K/Akt/NF-kB signal transduction pathway.

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Grant sponsor: Association pour la Recherche sur le Cancer (ARC); Grant sponsor: Fondation Recherche et Partage (Caisse d'Epargne); Grant sponsor: Fonds de Recherche de la Socie ´te ´Nationale Franc ¸aise de Gastroente ´rologie.

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