## Abstract Pregnancy reduces maternal risk of breast cancer in the long term, but the biological determinants of the protection are unknown. Animal experiments suggest that estrogens and progesterone could be involved, but direct human evidence is scant. A caseβcontrol study (536 cases and 1,049 c
IGF-I during primiparous pregnancy and maternal risk of breast cancer
β Scribed by Tianhui Chen; Annekatrin Lukanova; Kjell Grankvist; Anne Zeleniuch-Jacquotte; Marianne Wulff; Robert Johansson; Helena Schock; Per Lenner; Goran Hallmans; Goran Wadell; Paolo Toniolo; Eva Lundin
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 180 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0167-6806
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## Dear Sir, Our study is a meta-analysis of published research reports on the association of IGF-I with breast cancer risk. We did not focus on testosterone's link to breast cancer. Our analysis showed that levels of Insulin-Like Growth Factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) were hi
Earlier this year, we reported the results of a systematic review and meta-regression analysis determining the relationships between circulating total IGF-I and IGF binding protein-3 (IGFBP-3) concentrations and common cancer risk, including premenopausal and postmenopausal breast cancers. 1 Two sub
A high total number of full-term pregnancies is associated with a reduced risk of breast cancer, though pregnancy transiently increases the risk of the disease. However, little attention has been given to a possible association of breast cancer risk with the gender of offspring, even though male fet