IGF-I and TGF-beta 1 incorporated in a poly(d,l-lactide) implant coating maintain their activity over long-term storage—cell culture studies on primary human osteoblast-like cells

IGF-I and TGF-Beta 1 incorporated in a p

IGF-I and TGF-Beta 1 incorporated in a poly(D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation in cell culture

✍ G. Schmidmaier; B. Wildemann; M. Lübberstedt; N.P. Haas; M. Raschke 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB 👁 1 views

## Abstract Previous __in vivo__ studies revealed a stimulating effect of locally applied IGF‐I and TGF‐β1 released from poly(D,L‐lactide)‐coated titanium implants on rat and porcine fracture healing. The purpose of the present study was to evaluate the effect of IGF‐I (5% w/w) and TGF‐β1 (1% w/w)