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IGF-I and not IGF-II expression is regulated by glucocorticoids in human fetal epiphyseal chondrocytes

✍ Scribed by M. Fernandez-Cancio; C. Esteban; A. Carrascosa; N. Toran; P. Andaluz; L. Audi


Book ID
116512249
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
915 KB
Volume
18
Category
Article
ISSN
1096-6374

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Osteogenic protein-1 (OP-1 or BMP-7) stimulates new bone formation in vivo and induces cell proliferation and differentiation of osteoblasts in vitro. Previous studies from our laboratory revealed that OP-1 led to a two-to threefold increase in steady-state insulin-like growth factor-I (IGF-I) and I