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IGF binding protein-3 mediates stress-induced apoptosis in non-transformed mammary epithelial cells

✍ Scribed by Leibowitz, Brian J.; Agostini-Dreyer, Allyson; Jetzt, Amanda E.; Krumm, Christopher S.; Cohick, Wendie S.


Book ID
118762716
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
440 KB
Volume
228
Category
Article
ISSN
0021-9541

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IGF-I is mitogenic for the bovine mammary epithelial cell line MAC-T. In addition, IGF-I specifically upregulates IGFBP-3 synthesis in these cells. To investigate this effect on cell growth and IGF-I responsiveness, cell lines were developed that constitutively express IGFBP-3. MAC-T cells transfect