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IgE in patients with glomerulonephritis and minimal-change nephrotic syndrome

✍ Scribed by H. Schulte-Wissermann; W. Görtz; E. Straub

Publisher
Springer
Year
1979
Tongue
English
Weight
341 KB
Volume
131
Category
Article
ISSN
0340-6997

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✦ Synopsis

Serum levels of IgE were studied in 30 children with minimal-change nephrotic syndrome and 32 children with mesangioproliferative glomerulonephritis during different stages of the disease and treatment. In addition, tissue obtained by renal biopsy was investigated by immunofluorescence histology; no deposits of IgE could be found. The serum IgE levels, however, were increased, particularly in patients with minimal-change nephrotic syndrome. It is concluded that IgE does not play a pathogenic role in the development of the renal disease, but that increased IgE levels are an indication of a disturbance of the immune system.

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