IgA nephropathy associated with seronegative spondylarthropathies

✍ Scribed by J. Charles Jennette; Alfred L. Ferguson; Michael A. Moore; Douglas G. Freeman

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 650 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250205

✦ Synopsis

Abstract

Three patients with a seronegative spondylarthropathy were found to have IgA nephropathy. Two patients had ankylosing spondylitis (one with psoriasis), and one had incomplete Reiter's syndrome. All three had a focal proliferative glomerulonephritis with IgA‐dominant mesangial immune deposits. One patient had a leukocytoclastic vasculitis. This association of IgA nephropathy with seronegative spondylarthropathies raises the possibility of a common or related pathogenesis. There is evidence to suggest that both diseases are mediated by genetically controlled immune responses to mucosal contact with etiologic antigens.