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IFN-γ sensitizes MIN6N8 insulinoma cells to TNF-α-induced apoptosis by inhibiting NF-κB-mediated XIAP upregulation

✍ Scribed by Hun Sik Kim; Sunshin Kim; Myung-Shik Lee


Book ID
116291310
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
181 KB
Volume
336
Category
Article
ISSN
0006-291X

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl