IFN-γ-induced TNF-α is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophages by IFN-γ

Phenethyl isothiocyanate suppresses nitr

Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-γ secretion in LPS-activated peritoneal macrophages

✍ Toru Okubo; Kazuto Washida; Akira Murakami 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB

## Abstract Phenethyl isothiocyanate (PEITC), a constituent of many cruciferous vegetables, is well known to have versatile physiological activities, including chemopreventive effects. On the other hand, its anti‐inflammatory effects are poorly reported. Nitric oxide (NO) is associated with a wide