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IFN-γ and IL-12 Synergize to Convert in vivo Generated Th17 into Th1/17 Lineage Cells

✍ Scribed by Maria Lexberg; Annegret Taubner; Inka Albrecht; Anne Richter; Thomas Kamradt; Andreas Radbruch; Hyun-Dong Chang

Book ID
113541803
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
55 KB
Volume
135
Category
Article
ISSN
1090-2341

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IFN-γ and IL-12 synergize to convert in
IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells
✍ Maria H. Lexberg; Annegret Taubner; Inka Albrecht; Inga Lepenies; Anne Richter; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 536 KB

## Abstract Th1 and Th17 cells are distinct lineages of effector/memory cells, imprinted for re‐expression of IFN‐γ and IL‐17, by upregulated expression of T‐bet and retinoic acid‐related orphan receptor γt (RORγt), respectively. Apparently, Th1 and Th17 cells share tasks in the control of inflamma