IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease
✍ Scribed by David Polchert; Justin Sobinsky; GW Douglas; Martha Kidd; Ada Moadsiri; Eduardo Reina; Kristyn Genrich; Swati Mehrotra; Suman Setty; Brett Smith; Amelia Bartholomew
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 334 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract Graft‐versus‐host disease (GVHD) can occur following the transfer of allogeneic lymphocytes into immunosuppressed and, in rare cases, immunocompetent recipients. The initiation of GVHD requires the allorecognition of the recipient's disparate MHC molecules by the donor T lymphocytes (T
## Abstract Human bone marrow derived‐mesenchymal (skeletal) stem (MSC) cells are a group of non‐hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm‐type cells such as osteoblasts, chondrocytes and adipocyt