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If-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells

โœ Scribed by Annalisa Bucchi; Mirko Baruscotti; Richard B. Robinson; Dario DiFrancesco


Book ID
117142389
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
224 KB
Volume
35
Category
Article
ISSN
0022-2828

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Block of the cardiac pacemaker current (
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We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the