Idiotypic characteristics of λ1-bearing anti-α(1→3)dextran response in wild mice: high frequency of responder strains and co-expression of IdI 558 and IdI 104 on the same molecule
✍ Scribed by Dominique Juy; Anne-Marie Drapier; Jean-Louis Guenet; Pierre-André Cazenave
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 708 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Idiotypic characteristics of hl-bearing anti-a( h3)dextran response in wild mice: high frequency of responder strains and co-expression of Id1 558 and Id1 104 on the same molecule*
In laboratory mouse strains, only mice with the IghC" phenotype are able to mount an immune response against the a(l+3) glycosidic linkage of the B1355 dextran. The response is highly restricted with respect to utilization of only VLl and a few related members of the VH558 family, and characterized by the production of cross-reacting (IdX), and individual (IdI) 104 and 558 idiotopes. We report in this study data showing a large degree of polymorphism in the anti-a(l43)Dex response among 35 wild-derived mouse strains belonging to 4 different species. In contrast to the antia(l+3)Dex response of common laboratory strains, neither this response nor expression of the IdX, and Id1 104 and 558 idiotopes are linked to the IghC" haplotype. We also demonstrate co-expression on the same molecule of Id1 104 and Id1 558 idiotopes in wild mouse-derived hybridomas. These data challenge the idea of the exclusive expression at the molecular level of Id1 104 or Id1 558.