Idiotypic characteristics of immunoglobulins associated with human systemic lupus erythematosus: association of high serum levels of IdGN2 with nephritis but not with HLA class ii genes predisposing to nephritis
✍ Scribed by Bevra H. Hahn; Kenneth C. Kalunian; Zdenka Fronek; Niver Panosian-Sahakian; James S. Louie; Hugh O. Mcdevitt; Fanny M. Ebling
- Book ID
- 102754002
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 655 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Serum levels of IdGN2 (an idiotype enriched in nephritogenic antibodies), IdX (an idiotype not enriched in nephritogenic antibodies), IgG, and anti-DNA were measured in 2 3 Caucasian patients with lupus nephritis, in age-and sex-matched lupus patients without nephritis, and in similarly matched healthy individuals. Serum levels of IdGN2 were significantly higher in the patients with lupus nephritis than in those without. and they were higher in all lupus patients compared with the healthy control subjects. However, the same observations were true for serum levels of IdX. There were significant positive correlations between the serum levels of IgG, IdGN2, IdX, and anti-DNA. HLA typing at the DR and DQ loci was performed in 105 lupus patients of different races (Caucasian, black, and Asian/Polynesian/ Filipino). Serum levels of IdGN2 in 83 of these individ--_ _