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IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia and associated with NPM1 mutations and FAB-M2 subtype

โœ Scribed by H.-Y. CHAO; Z.-X. JIA; T. CHEN; X.-Z. LU; L. CEN; R. XIAO; N.-K. JIANG; J.-H. YING; M. ZHOU; R. ZHANG


Book ID
114897896
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
163 KB
Volume
34
Category
Article
ISSN
1751-5521

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Mutations of CEBPA in acute myeloid leuk
โœ Jennifer Snaddon; Matthew L. Smith; Michael Neat; Maxine Cambal-Parrales; Amanda ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 445 KB

CEBPA encodes the transcription factor C/EBPalpha and is specifically up-regulated during granulocytic differentiation. The gene is mutated in approximately 20% of patients with acute myeloid leukemia (AML) FAB type M2 and occurs in the absence of the t(8;21). In much the same way as specific transl