Mutations in the gene encoding the isocitrate dehydrogenase 1 gene (IDH1) occur at a high frequency (up to 80%) in many different subtypes of glioma. In this study, we have screened for IDH1 mutations in a cohort of 496 gliomas. IDH1 mutations were most frequently observed in low grade gliomas with
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
โ Scribed by Linda B. C. Bralten; Nanne K. Kloosterhof; Rutger Balvers; Andrea Sacchetti; Lariesa Lapre; Martine Lamfers; Sieger Leenstra; Hugo de Jonge; Johan M. Kros; Erwin E. W. Jansen; Eduard A. Struys; Cornelis Jakobs; Gajja S. Salomons; Sander H. Diks; Maikel Peppelenbosch; Andreas Kremer; Casper C. Hoogenraad; Peter A. E. Sillevis Smitt; Pim J. French
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 855 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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