Identity of coleonol with forskolin: structure revision of a base-catalysed rearrangement product
β Scribed by Anil K. Saksena; Michael J. Green; Ho-Jane Shue; Jesse K. Wong; Andrew T. McPhail; Paul M. Gross
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 258 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
The identity of coleonol and forskolin is shown through structure revision of a rearrangement product isolated earlier from coleonol and is confirmed by direct comparison of authentic coleonol with forskolin 1; in addition, coleonol-B should be correctly represented by structure _4_.
π SIMILAR VOLUMES
Reaction of gmelinol 1 with BF3-etherate followed by treatment with various additives gave two isomeric woducts 2 and $ formed by rearrangement of the 2,6-diaryl-3,7-dioxabizyclo[3.3.0]oetane skeleton. Compounds 2 and S on oxidation with DDQ in trifluor~\_\_~ic acid or benzene produced enantiomers $
## Abstract A molluskβspecific toxin, TxVIIA, having potent paralytic activity was isolated from the venom of sea snail __Conus textile__ (Fainzilber M et al., 1991, __Eur J Biochem 202__:589β595). The structure reported above was based upon amino acid analysis and the Edman degradation. We have re