✦ LIBER ✦

Identifying global anatomical differences: Deformation-based morphometry

✍ Scribed by John Ashburner; Chloe Hutton; Richard Frackowiak; Ingrid Johnsrude; Cathy Price; Karl Friston

Book ID: 101232760
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 462 KB
Volume: 6
Category: Article
ISSN: 1065-9471
DOI: 10.1002/(sici)1097-0193(1998)6:5/6<348::aid-hbm4>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

The aim of this paper is to illustrate a method for identifying macroscopic anatomical differences among the brains of different populations of subjects. The method involves spatially normalizing the structural MR images of a number of subjects so that they all conform to the same stereotactic space. Multivariate statistics are then applied to the parameters describing the estimated nonlinear deformations that ensue. To illustrate the method, we compared the gross morphometry of male and female subjects. We also assessed brain asymmetry, the effect of handedness, and interactions among these effects.

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