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Identifying and quantifying apoptosis: a growth industry in the face of death

✍ Scribed by Alison, Malcolm R.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
118 KB
Volume
188
Category
Article
ISSN
0022-3417

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✦ Synopsis

Apoptosis remains one of the hottest topics in cell biology, and great strides are being made in unravelling the complex interplay between the various regulatory molecules, particularly between the mammalian homologues of the nematode Caenorhabdtis elegans death regulatory proteins Ced-3, Ced-4 and Ced-9. Curiously, the relative merits of the seemingly simple methodologies to visualize and quantify apoptosis still provoke considerable debate. Many are based on the ability to detect DNA breaks by enzyme-mediated addition of labelled nucleotides, but the capricious nature of many of the available labelling kits, combined with a lack of true specificity, continues to fuel the search for more reliable apoptosis 'markers'.

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