Identification Strategy Using Combined Mass Spectrometric Techniques for Elucidation of Phase I and Phase II in Vitro Metabolites of Lipophilic Marine Biotoxins

Rapid identification of phase I and II m

Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

✍ Tian Liu; Fuying Du; Yakun Wan; Fanping Zhu; Jie Xing 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract Artemisinin drugs have become the first‐line antimalarials in areas of multi‐drug resistance. However, monotherapy with artemisinin drugs results in comparatively high recrudescence rates. Autoinduction of CYP‐mediated metabolism, resulting in reduced exposure, has been supposed to be t