✦ LIBER ✦

Identification of urinary catechol and methylated catechol metabolites of phenytoin in humans, monkeys, and dogs by GLC and GLC-mass spectrometry

✍ Scribed by K. K. Midha; K. W. Hindmarsh; I. J. McGilveray; J. K. Cooper

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 563 KB
Volume: 66
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600661124

No coin nor oath required. For personal study only.

✦ Synopsis

A catechol metabolite, 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin, and a methylated catechol metabolite, 5-(3-methoxy-4-hydroxyphenyl)-5-phenylhydantoin, were identified as urinary metabolites in humans, monkeys, and dogs following the administration of phenytoin. These metabolites were separated from each other and from other known metabolites of phenytoin as n-butyl derivatives by GLC and positively identified by combined GLC-mass spectrometry.

📜 SIMILAR VOLUMES

Identification of nonpolar methotrimepra

Identification of nonpolar methotrimeprazine metabolites in plasma and urine by GLC-mass spectrometry

✍ Svein G. Dahl; Mats Garle 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB 👁 1 views

Simultaneous determination of etoposide

Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry

✍ Shaokun Pang; Naiyu Zheng; Carolyn A. Felix; Jennifer Scavuzzo; Ray Boston; Ian 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 2 views

The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication. The genotype of cytochrome P450 3A4 (CYP3A4), which converts etoposide to its catechol metabolite, influences the risk. In order to perform pharmacokinetic st

Identification of oestrogen metabolites

Identification of oestrogen metabolites in human urine by capillary gas chromatography and mass spectrometry

✍ Karin Gerhardt; Helga Ludwig-Köhn; Hans Victor Henning; Gerd Remberg; Axel Zeeck 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 732 KB

Oestrogen metabolites from the urine of males and pregnant and non-pregnant females were enriched by a procedure involving column chromatography on adsorber resins, gels and ion exchangers, enzymatic solvolysis and extraction, thereby separating the oestrogens from most of the interfering material.

Identification and determination of the

Identification and determination of the S-methyl metabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry

✍ Allen I. Cohen; Eugene Ivashkiv; Terrence McCormick; Doris N. McKinstry 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 336 KB 👁 2 views

Determination of captopril in human bloo

Determination of captopril in human blood and urine by GLC-selected ion monitoring mass spectrometry after oral coadministration with its isotopomer

✍ Allen I. Cohen; Richard G. Devlin; Eugene Ivashkiv; Phillip T. Funke; Terrence M 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 679 KB

A modified electron-impact GLC-selected ion monitoring mass spectrometric method for captopril is described. Positive chemical ionization GLC-selected ion monitoring and direct chemical ionization confirms the specificity of this procedure for captopril and establishes the chemical ionization techni

Rapid characterization of urinary metabo

Rapid characterization of urinary metabolites of pibutidine hydrochloride in humans by liquid chromatography/electrospray ionization tandem mass spectrometry

✍ K. Kato; S. Jingu; N. Ogawa; S. Higuchi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

The metabolic products of pibutidine hydrochloride, a new H 2 -receptor antagonist, in human urine after oral administration of 40 mg/man were characterized by high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). Two-stage collision-induced d