✦ LIBER ✦
Identification of Unique Fragments in Overlapping Large-Insert Clones by Subtraction through Representational Difference Analysis
✍ Scribed by Massimo Romani; Jula V.M. Marchi; Barbara Banelli; Ida Casciano
- Book ID
- 102559111
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 107 KB
- Volume
- 271
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
✦ Synopsis
The identification of disease genes in the absence of information about biological defects is referred as "positional cloning." This strategy is initiated by mapping the responsible gene to a chromosome by genetic linkage or cytogenetic studies. The candidate interval region is then restricted until the correct gene is identi-