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Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing

✍ Scribed by Powell, Bradford C.; Jiang, Lichun; Muzny, Donna M.; Treviño, Lisa R.; Dreyer, ZoAnn E.; Strong, Louise C.; Wheeler, David A.; Gibbs, Richard A.; Plon, Sharon E.


Book ID
118237983
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
282 KB
Volume
60
Category
Article
ISSN
1545-5009

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The t(9;11) has been described in patients with acute myeloid leukemia (AML), and two genes [AF9 (at 9p21) and FBP17 (at 9q34)] have been cloned as fusion partners of the MLL gene. From an AML-M5 with a t(9;11)(q34;q23), we identified a novel MLL fusion partner, AF9Q34. The AF9Q34 protein shows high