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Identification of tooth-specific downstream targets of Runx2

✍ Scribed by Joel S Gaikwad; Adriana Cavender; Rena N D'Souza


Book ID
117520609
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
289 KB
Volume
279
Category
Article
ISSN
0378-1119

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## Abstract In recent years, the in vivo role of the three members of the RUNX family of transcription factors has in part been elucidated. While Runx1 is essential for mature haematopoiesis and Runx2 for osteochondrogenesis, Runx3 has a function in the nervous system. Translocations and mutations

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## Abstract Runx2 is an osteoblast master transcription factor and a target for bone morphogenetic protein (BMP) signaling, but our knowledge of events downstream of Runx2 is limited. In this study, we used ChIP Display to discover seven novel genomic regions occupied by Runx2 in living MC3T3‐E1 os