Identification of threonine 422 in transmembrane domain αM4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone
✍ Scribed by Ingrid Garbus; Ana M Roccamo; Francisco J Barrantes
- Book ID
- 117187382
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 462 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0028-3908
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## Abstract The αM4 transmembrane domain of the nicotinic acetylcholine receptor (AChR) is flanked by two basic amino acids (His^408^ and Arg^429^) located at its cytoplasmic‐ and extracellular‐facing extremes, respectively, at the level of the phospholipid polar head regions of the postsynaptic me
The ␣4 subunit gene of the neuronal nicotinic acetylcholine receptor (CHRNA4) has recently been identified as the first gene underlying an idiopathic partial epilepsy syndrome in human, autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE). CHRNA4 is located in the candidate region for benign