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Identification of the Uridine Diphosphate Glucuronosyltransferase Isoform UGT1A6 in Rat Brain and in Primary Cultures of Neurons and Astrocytes

✍ Scribed by Funmilayo G. Suleman; Amr Abid; Daniela Gradinaru; Jean-Luc Daval; Jacques Magdalou; Alain Minn


Book ID
115567283
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
101 KB
Volume
358
Category
Article
ISSN
0003-9861

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The regulation of intracellular cyclic AMP (CAMP) formation by adenosine (Ado) and its analogues has been examined in primary cultures of rat-brain astrocytes and neurons. In the presence of the phosphodiesterase inhibitor, Ro 20-1724, basal levels of cAMP ranged from 40-120 pmoVmg protein in both c