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Identification of the site of glycation of human insulin

✍ Scribed by Finbarr P.M. O'Harte; Peter Højrup; Christopher R. Barnett; Peter R. Flatt


Book ID
117408867
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
955 KB
Volume
17
Category
Article
ISSN
0196-9781

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## Abstract Our previous investigation indicated that insulin can be nitrated by peroxynitrite __in vitro__. In this study, the preferential nitration site of the four tyrosine residues in insulin molecule was confirmed. Mononitrated and dinitrated insulins were purified by RP‐HPLC. Following reduc