## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi
β¦ LIBER β¦
Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8
β Scribed by Henry L. Puhl III; Stephen R. Ikeda
- Book ID
- 111180946
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 899 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0022-3042
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## Abstract Voltageβgated sodium channels play critical roles in the excitability of the brain. A decreased level of Na~v~1.1 has been identified as the cause of severe myoclonic epilepsy in infancy. In the present study, we identified the transcription start site and three 5β²βuntranslated exons of