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Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

✍ Scribed by Peter J. Lockyer; Stefan Wennström; Sabine Kupzig; Kanamarlapudi Venkateswarlu; Julian Downward; Peter J. Cullen


Book ID
114321463
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
115 KB
Volume
9
Category
Article
ISSN
0960-9822

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The t(9;11) has been described in patients with acute myeloid leukemia (AML), and two genes [AF9 (at 9p21) and FBP17 (at 9q34)] have been cloned as fusion partners of the MLL gene. From an AML-M5 with a t(9;11)(q34;q23), we identified a novel MLL fusion partner, AF9Q34. The AF9Q34 protein shows high