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Identification of the proximate peroxisome proliferator(s) derived from Di(2-ethylhexyl) phthalate

✍ Scribed by Angela M. Mitchell; Jean-Claude Lhuguenot; James W. Bridges; Clifford R. Elcombe

Book ID: 113206444
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 821 KB
Volume: 80
Category: Article
ISSN: 0041-008X
DOI: 10.1016/0041-008x(85)90097-3

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Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator whose administration to rodents induces a pleiotropic response mediated by the peroxisome proliferator-activated receptor-alpha (PPAR alpha). The mechanisms underlying DEHP-induced reproductive toxicity and teratogenicity are not well un