Identification of the origin of triploidy by HLA markers
✍ Scribed by P. Couillin; J. Hors; J. Boué; A. Boué
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 438 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
HLA-A and HLA-B markers have been determined in fibroblasts grown from tissues of triploid conceptuses and have been tested in the parents. Informative data on the origin of triploidy were obtained in eight cases: diandry I or dispermy in 4 cases, diandry II or dispermy in 2, digyny I or II in 2. This confirms that triploidy involved more frequently two sets of paternal chromosomes.
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One hundred and seventy-nine patients with various forms of glomerulonephritis confirmed histologically were tested for HLA A and B antigens: Thirty-four with membranous glomerulonephritis were also typed for DR antigens. One hundred and forty-one of these patients were further tested for blood grou