✦ LIBER ✦

Identification of the fibroblast growth factor receptor in human vascular endothelial cells

✍ Scribed by Gera Neufeld; Denis Gospodarowicz

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 728 KB
Volume: 136
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041360321

No coin nor oath required. For personal study only.

✦ Synopsis

The fibroblast growth factor (FGF) receptor of human umbilical vein-derived endothelial (HUE) cells has been identified by affinity labeling. It has an apparent molecular weight of 130,000. It binds both basic and acidic FGF, but not with epidermal growth factor, insulin, or transferrin. The lectin concanavalin-A does not inhibit the binding of '251-bFCF to HUE cell-surface receptors, whereas it inhibits bFGF binding to BHK-21 cell-surface FGF receptor. This suggests that both types of receptors may differ in their degree of glycosylation. In contrast to other cell types, heparin only slightly inhibits the binding of basic FGF to its receptor. Protamine sulfate, which is anti-angiogenic in vivo, and surarnin, a drug used in the therapy of trypanosomiasis and onchocerciasis. also inhibit the binding of basic FGF to the receptor.

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