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Identification of the Epitope for Monoclonal Antibody 4B1 Which Uncouples Lactose and Proton Translocation in the Lactose Permease of Escherichia coli

✍ Scribed by Sun, Jianzhong; Wu, Jianhua; Carrasco, Nancy; Kaback, H. Ronald


Book ID
126041391
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
452 KB
Volume
35
Category
Article
ISSN
0006-2960

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Binding of monoclonal antibody 4B1 to ho
✍ Jianzhong Sun; Stathis Frillingos; H. Ronald Kaback πŸ“‚ Article πŸ“… 1997 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 695 KB

The conformationally sensitive epitope for monoclonal antibody (mAb) 4B1, which uncouples lactose from H+ translocation in the lactose permease of Escherichia coli, is localized in the periplasmic loop between helices VII and VIII (loop VII/VIII) on one face of a short helical segment (Sun J, et al.