## Abstract ## Objective To analyze spontaneous T cell spreading against determinants of the U1β70K protein in young autoimmune MRL/__lpr__ lupus mice, in comparison with the T cell spreading occurring in normal BALB/c mice immunized with peptide 131β151 of this protein. ## Methods Peripheral bl
β¦ LIBER β¦
Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells
β Scribed by Mei-Hui Yang; Jau-Ling Suen; Shiao-Lan Li; Bor-Luen Chiang
- Book ID
- 108781664
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 181 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0019-2805
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## Abstract Modifications of self antigens that occur during apoptosis might be involved in the generation of neoβantigens, which can break tolerance and induce autoimmunity. We have previously identifiedan epitope at residues 131β151 of the U1β70K snRNP protein, recognized by IgG antibodies and CD
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