Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts. Cytometry 31:242–250, 1998

Identification of SV40 T-antigen mutants

Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts

✍ F. Andrew Ray; Mary Jo Waltman; John M. Lehman; John B. Little; Jac A. Nickoloff 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 2 views

The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immortal