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Identification of Small Molecules That Selectively Inhibit Diacylglycerol Lipase–α Activity

✍ Scribed by Appiah, Kingsley K. ;Blat, Yuval ;Robertson, Barbara J. ;Pearce, Bradley C. ;Pedicord, Donna L. ;Gentles, Robert G. ;Yu, Xuan-Chuan ;Mseeh, Faika ;Nguyen, Nghi ;Swaffield, Jonathan C. ;Harden, David G. ;Westphal, Ryan S. ;Banks, Martyn N. ;O’Connell, Jonathan C.

Book ID
125550325
Publisher
SAGE Publications
Year
2014
Tongue
English
Weight
988 KB
Volume
19
Category
Article
ISSN
2472-5552

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## Abstract The diacylglycerol lipases (DAGLα and DAGLβ) synthesize 2‐arachidonoylglycerol (2‐AG), a full agonist at cannabinoid receptors. Dynamic regulation of DAGL expression underpins its role in axonal growth and guidance during development, retrograde synaptic signalling at mature synapses, a