Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
✍ Scribed by Dijke, Peter ten; Nakao, Atsuhito; Afrakhte, Mozhgan; Morn, Anita; Nakayama, Takuya; Christian, Jan L.; Heuchel, Rainer; Itoh, Susumu; Kawabata, Masahiro; Heldin, Nils-Erik; Heldin, Carl-Henrik
- Book ID
- 109799984
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 506 KB
- Volume
- 389
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/39369
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for
## Abstract The transforming growth factor‐β (TGFβ) family represents a class of signaling molecules that plays a central role in morphogenesis, growth, and cell differentiation during normal embryonic development. Members of this growth factor family are particularly vital to development of the ma