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Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene

✍ Scribed by Palacín, Manuel; Torrents, David; Mykkänen, Juha; Pineda, Marta; Feliubadaló, Lidia; Estévez, Raúl; Cid, Rafael de; Sanjurjo, Pablo; Zorzano, Antonio; Nunes, Virginia; Huoponen, Kirsi; Reinikainen, Arja; Simell, Olli; Savontaus, Marja-Liisa; Aula, Pertti

Book ID
109826940
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
602 KB
Volume
21
Category
Article
ISSN
1061-4036

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Two distinct human light subunits of the heteromeric amino acid transporter, y+LAT-1 coded by SLC7A7 and y+LAT-2 coded by SLC7A6, are both known to induce transport system y+L activity. SLC7A7 has already been identified as the gene responsible for lysinuric protein intolerance (LPI). We successfull